余美靜

Abstract:

Vibrational spectroscopy including attenuated Total Reflection Fourier-Transform Infrared (ATR-FTIR) spectroscopy and Ramman spectroscopy has emerged as a promising liquid biopsy platform offering label-free, non-destructive, and rapid molecular fingerprinting of biofluids. In the context of precision medicine, this technique enables high-throughput spectral analysis of blood, capturing complex biochemical alterations associated with disease states.

Building on our prior work in autoimmune and inflammatory glomerulonephritis, ATR-FTIR demonstrated the ability to detect disease-specific molecular signatures in serum. Our findings suggest that ATR-FTIR can sensitively distinguish spectral patterns in blood associated with disease severity, treatment response, and disease outcome. These distinct vibrational profiles reflect dynamic changes in circulating biomolecules, including proteins, lipids, and nucleic acids. We are now expanding its application to oncology and explore its capabilities in tumour progression, treatment response, and recurrence

This talk will highlight the potential of ATR-FTIR spectroscopy as a liquid biopsy tool across diverse biomedical applications. We will present data validating its diagnostic accuracy in immune-related kidney diseases and explore its translational potential in disease detection and longitudinal patient monitoring. Ultimately, ATR-FTIR offers a scalable, cost-effective platform for non-invasive diagnostics, bridging the gap between molecular pathology and personalized healthcare.

Keywords – Infrared spectroscopy, liquid biopsy, glomerulonephritis,

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